Risk factors of cognitive dysfunction and its relationship with poor prognosis in elderly hypertensive pa-tients with frailty
10.3969/j.issn.1008-0074.2024.04.03
- VernacularTitle:老年高血压伴衰弱患者认知功能障碍的危险因素及与不良预后的关系
- Author:
Can ZHAO
1
;
Shan-Shan LIU
;
Jing-Bing LI
;
Shao-Ying WANG
;
Li-Di WANG
;
Jun-Fu LIU
Author Information
1. 河北省第八人民医院心内科,河北石家庄 050000
- Keywords:
Hypertension;
Cognition disorders;
Risk factors;
Prognosis
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(4):391-394
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the risk factors of cognitive dysfunction and its relationship with poor prognosis in elderly hypertensive patients with frailty.Methods:A total of 150 elderly hypertensive patients with frailty trea-ted in Eighth People's Hospital of Hebei Province from July 2019 to March 2021 were selected.According to pres-ence of cognitive dysfunction,they were divided into normal cognition group(n=92)and cognitive dysfunction group(n=58),and general data and prognosis condition were collected in two groups.Multivariate Logistic regres-sion analysis was used to analyze the risk factors of cognitive dysfunction in elderly hypertensive patients with frail-ty;Spearman correlation analysis was used to analyze the correlation between cognitive dysfunction degree and prog-nosis.Results:Compared with normal cognition group,cognitive dysfunction group was significantly older and pos-sessed significant higher proportions of diabetes,coronary heart disease,stroke,hyponatremia,multiple medication and malnutrition(P＜0.05 or＜0.01).Multivariate Logistic regression analysis indicated that age ≥75 years,stroke,multiple medication and malnutrition were independent risk factors for cognitive dysfunction in elderly hy-pertensive patients with frailty(OR=2.804～6.434,P＜0.05 or＜0.01).Incidence rate of poor prognosis events in cognitive dysfunction group was significantly higher than that of normal cognition group(51.72％vs.11.96％,P＜0.001).Spearman correlation analysis showed that cognitive dysfunction was significant positively correlated with poor prognosis in these patients(r=0.435,P＜0.001).Conclusion:Age,stroke,multiple medication and malnu-trition are independent risk factors for cognitive dysfunction in elderly hypertensive patients with frailty.Cognitive dysfunction is closely related to poor prognosis in these patients.
