Efficacy and safety analysis of hypoxia-inducible factor prolyl hydroxylase inhibitors for anemia in low-risk myelodysplastic syndromes patients
10.3760/cma.j.cn121090-20230825-00089
- VernacularTitle:低危骨髓增生异常综合征患者应用低氧诱导因子脯氨酰羟化酶抑制剂治疗贫血的疗效和安全性分析
- Author:
Yue LYU
1
;
Zenghua LIN
;
Li YANG
;
Hong LIU
Author Information
1. 南通大学附属医院血液内科、南通大学医学院，南通 226001
- From:
Chinese Journal of Hematology
2024;45(3):290-293
- CountryChina
- Language:Chinese
-
Abstract:
Myelodysplastic syndromes is a heterogeneous group of myeloid neoplastic disorders originating from hematopoietic stem cells and manifesting as pathological bone marrow hematopoiesis and a high risk of transformation to acute myeloid leukemia. In low-risk patients, the therapeutic goal is to improve hematopoiesis and quality of life. Roxadustat is the world's first oral small-molecule hypoxia-inducible factor prolyl hydroxylase inhibitor, which, unlike conventional erythropoietin, corrects anemia through various mechanisms. In this study, we retrospectively analyzed the changes in anemia, iron metabolism, lipids and inflammatory indexes in patients with low-risk myelodysplastic syndromes to evaluate its therapeutic efficacy and safety, and to provide theoretical and practical data for the application of roxadustat in myelodysplastic syndromes.
