Research progress of risk factors affecting prognosis of hypertrophic cardiomyopathy in children
10.3760/cma.j.issn.1673-4912.2024.11.012
- VernacularTitle:影响儿童肥厚型心肌病预后的相关危险因素研究进展
- Author:
Zhiyu TIAN
1
;
Zhen ZHEN
;
Lu GAO
;
Yue YUAN
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院心脏内科100045
- Keywords:
Hypertrophic cardiomyopathy;
Prognosis;
Sudden cardiac death;
Risk factors
- From:
Chinese Pediatric Emergency Medicine
2024;31(11):861-866
- CountryChina
- Language:Chinese
-
Abstract:
Hypertrophic cardiomyopathy (HCM) in children is one of the most common hereditary cardiomyopathies caused by gene mutations encoding cardiac carcomeric proteins. It is mainly characterized by ventricular hypertrophy and non-enlarged cardiac chambers, with a potential risk of sudden cardiac death. Usually, the assessment is based on the general condition, clinical symptoms, imaging examination results, family history, and genetic testing of the patients, thereby providing a basis for judging the risk of sudden cardiac death, and then identifying the risk factors for sudden cardiac death in hypertrophic cardiomyopathy. Based on the relevant domestic and foreign literature in recent years and the accumulated work experience in the department of cardiology of Beijing Children's Hospital, these risk factors are divided into major and minor risk factors. A comprehensive understanding of these risk factors can guide the clinical early warning of high-risk children with possible sudden death, which is helpful for more accurate assessment of the prognosis of hypertrophic cardiomyopathy in children and the implementation of targeted intervention. This article reviewed the research progress of related risk factors for the prognosis of hypertrophic cardiomyopathy in children.
