Validation of New Symptom-Based Fibromyalgia Criteria for Irritable Bowel Syndrome Co-morbidity Studies.
- Author:
Ami D SPERBER
1
;
Smadar AKIVA
;
Moshe LESHNO
;
Zamir HALPERN
;
Dan BUSKILA
Author Information
1. Department of Gastroenterology, Soroka Medical Center, Beer-Sheva, Israel. amy@bgu.ac.kr
- Publication Type:Original Article
- Keywords:
Comorbidity;
Fibromyalgia;
Irritable bowel syndrome;
Physical examination
- MeSH:
Comorbidity;
Fatigue;
Female;
Fibromyalgia;
Humans;
Irritable Bowel Syndrome;
Physical Examination;
Surveys and Questionnaires;
Rheumatology;
Sensitivity and Specificity
- From:Journal of Neurogastroenterology and Motility
2011;17(1):67-72
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: There is significant co-morbidity between irritable bowel syndrome (IBS) and fibromyalgia syndrome (FMS). However, FMS is diagnosed by physical examination, which limits the conduct of co-morbidity studies in a large population-based study. The purpose of this study was to determine the diagnostic validity of a new symptom-based criteria in patients with FMS and/or IBS using the American College of Rheumatology (ACR) criteria as a gold standard. METHODS: The study participants consisted of women with FMS (n = 30), IBS (n = 27) and controls (n = 28). A new symptom-based diagnostic criteria for FMS comprised a regional pain scale and a visual analogue scale for fatigue. All subjects underwent a physical examination for FMS (ACR criteria) and structured questionnaires of regional pain scale and visual analogue scale for fatigue. A fibromyalgia intensity score was calculated and thresholds of tenderness were determined by a dolorimeter. RESULTS: The number of participants diagnosed with FMS in the entire study population (n = 85) was 31 by the new criteria. Compared to the ACR, the sensitivity of the new criteria was 82.9%, specificity 96.0%, positive predictive value 93.5% and negative predictive value 88.9%. In addition, new criteria were useful for the diagnosis of FMS among the subjects with IBS. A fibromyalgia intensity score was significantly correlated with the threshold of tenderness (r = -0.62, P < 0.001). CONCLUSIONS: The new symptom-based diagnostic criteria for the diagnosis of FMS can be used in large-scale clinical and epidemiological co-morbidity studies, in which physical examination is unfeasible. Gastroenterologists investigating the effects of co-morbid FMS in IBS patients can use these new ciriteria with confidence.
