Coordinating tissue repair: molecular pathways controlling the function of harmful and repairing neutrophils
10.3760/cma.j.cn501225-20240306-00089
- VernacularTitle:协调组织修复：控制有害和修复性中性粒细胞功能的分子途径
- Author:
Weifeng HE
1
;
Lingfeng YAN
Author Information
1. 陆军军医大学（第三军医大学）第一附属医院全军烧伤研究所，创伤与化学中毒全国重点实验室，重庆市创面损伤修复与再生重点实验室，重庆 400038
- Keywords:
Wound healing;
Immunity;
Inflammation;
Neutrophils;
Molecular pathways
- From:
Chinese Journal of Burns
2024;40(5):407-414
- CountryChina
- Language:Chinese
-
Abstract:
Neutrophils are the most abundant circulating white blood cells and play an indispensable role as first responders of damaged tissue and infected sites in the early inflammatory response of healing. Neutrophils provide immediate host defense by engulfing and destroying pathogens, releasing cytotoxic enzymes and metabolites, and spreading inflammatory networks. However, if left uncontrolled, these defense mechanisms can cause significant collateral damage. Focusing on the triggers of harmful neutrophil inflammation and immunomodulatory deficits, as well as grasping the specific drivers of harmful inflammation, is of great significance for recalibrating inflammation to promote endogenous tissue repair. This article, starting from the causes of neutrophil inflammation imbalance, elaborated the main mechanism of neutrophil-mediated tissue injury and related pathological manifestations, and highlighted the therapeutic targets with promising applications.
