Research advances on the role of aerobic glycolysis in skin fibrosis diseases
10.3760/cma.j.cn501225-20230712-00004
- VernacularTitle:有氧糖酵解在皮肤纤维化疾病中的作用研究进展
- Author:
Lixia ZHANG
1
;
Dahai HU
Author Information
1. 空军军医大学第一附属医院全军烧伤中心，烧伤与皮肤外科，西安 710032
- Keywords:
Cicatrix;
Skin diseases;
Glycolysis;
Fibrosis;
Fibroblasts
- From:
Chinese Journal of Burns
2024;40(4):389-394
- CountryChina
- Language:Chinese
-
Abstract:
Skin fibrosis diseases mainly include hypertrophic scar, keloid, and systemic sclerosis, etc. The main pathological features are excessive activation of fibroblasts and abnormal deposition of extracellular matrix. In recent years, studies have shown that aerobic glycolysis is closely related to the occurrence and development of skin fibrosis diseases. Drugs targeting aerobic glycolysis has provided new ideas for skin anti-fibrosis treatment. This article reviews the role of enzymes and products related to aerobic glycolysis in the occurrence and development of skin fibrosis diseases and the drugs targeting aerobic glycolysis for the treatment of skin fibrosis diseases.
