Research advances on the role of microRNA engineered exosomes in diabetic wounds
10.3760/cma.j.cn501225-20230721-00011
- VernacularTitle:微小RNA工程化外泌体在糖尿病创面中的作用研究进展
- Author:
Xichao JIAN
1
;
Chengliang DENG
Author Information
1. 遵义医科大学附属医院烧伤整形外科，遵义 563003
- Keywords:
Exosomes;
MicroRNAs;
Diabetes mellitus;
Wound repair
- From:
Chinese Journal of Burns
2024;40(2):190-195
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic wounds are a common complication in patients with diabetes, which is difficult to treat. Current treatment methods for diabetic wounds include debridement, functional dressing coverage, negative pressure therapy, bone cement filling, and skin grafting, etc. MicroRNA (miRNA) engineered exosomes have shown promising potential in diabetic wound repair due to the ability to alleviate inflammation, stimulate angiogenesis, and promote collagen deposition and re-epithelialization. Related researches are being actively carred out. This paper reviews the pathophysiological characteristics of diabetic wounds, the characteristics of miRNA and exosomes, the engineering methods for exosomes loaded with miRNA, and the mechanism of miRNA engineered exosomes in promoting healing of diabetic wounds, aiming to provide a reference basis for the future clinical application of miRNA engineered exosomes in diabetic wounds.
