Research Progress of M1/M2 Microglia Involved in Central Pathogenesis of Acute Tinnitus

VernacularTitle:M1/M2小胶质细胞参与急性耳鸣中枢发病机制的研究进展
Author: Qing XIA ¹ ; Jianning ZHANG
Author Information

1. 上海中医药大学附属岳阳中西医结合医院耳鼻咽喉科(上海 200437)
Keywords: Tinnitus; M1/M2 microglia; Neuroinflammation; Neurotrophic factor
From: Journal of Audiology and Speech Pathology 2024;32(5):470-473
CountryChina
Language:Chinese
Abstract: Microglia cells are unique macrophages of the central nervous system,which play an important role in nerve injury,repair and remodeling.The functional abnormalities of the central auditory pathway and limbic sys-tem,as well as neural structure and functional remodeling are the focus of the central mechanism of tinnitus.M1 and M2 microglia participate in neural remodeling through pro-inflammatory and anti-inflammatory responses,respec-tively.In recent years,studies have found that microglia are involved in the pathogenesis of acute tinnitus by relea-sing their related cytokines,but the specific mechanism is still unclear.This study reviewed the research progress of M1 and M2 microglia in the mechanism of acute tinnitus.