Application value of neutrophil gelatinase associated lipocalin in clinical diagnosis of Crohn's disease
- VernacularTitle:中性粒细胞明胶酶相关脂质运载蛋白在克罗恩病临床诊断中的应用价值
- Author:
Kai MA
1
;
Yibo YAO
;
Chen WANG
Author Information
- Keywords: Crohn disease; lipocalin-2; diagnosis; neutrophil gelatinase associated lipocalin
- From: Tianjin Medical Journal 2024;52(10):1116-1120
- CountryChina
- Language:Chinese
- Abstract: Crohn's disease(CD)is an autoimmune intestinal disease characterised by chronic and non-specific inflammation,and the exact etiology and pathogenesis are still unclear.Neutrophil gelatinase associated lipocalin(NGAL),a secreted glycoprotein and isolated from neutrophils,is widely involved in pathophysiological processes such as intestinal inflammation response,apoptosis and tumour progression.It has been found that NGAL has the potential to be a clinical biological marker in clinical diagnosis and monitoring of CD activity.Therefore,this paper reviews the application value of NGAL in different clinical samples of CD,in order to provide reference for clinical diagnosis and treatment of CD.
