Research progress on the mechanism of ASIC1a-mediated chondrocyte injury in rheumatoid arthritis
- VernacularTitle:ASIC1a介导类风湿关节炎软骨细胞损伤机制的研究进展
- Author:
Yumei ZHONG
1
;
Haiyan ZHOU
;
Min ZHANG
Author Information
- Keywords: arthritis,rheumatoid; chondrocytes; acid sensing ion channels; apoptosis; extracellular acidification
- From: Tianjin Medical Journal 2024;52(9):1004-1008
- CountryChina
- Language:Chinese
- Abstract: Rheumatoid arthritis(RA)is a clinically refractory autoimmune disease.The destruction of bone and articular cartilage is a key pathological feature in the middle and late stages of RA.Acid-sensing ion channel 1a(ASIC1a)is a member of extracellular H+activated cation channel family,which can transmit low pH signal from extracellular microenvironment into cells,activate downstream pathways and induce a series of pathological changes.New evidence shows that ASIC1a plays a key role in the pathogenesis of RA,promoting joint inflammation,synovial hyperplasia and the destruction of bone and articular cartilage,which is of great significance in the pathological process of disease.In this paper,the molecular characteristics of ASIC1a are briefly reviewed,and the possible mechanism of ASIC1a to improve cartilage injury of RA is emphasized,so as to provide new ideas for the treatment of RA.
