Progress of Molecular Imaging Probes Targeting Granzyme B
10.3870/j.issn.1672-0741.23.12.005
- VernacularTitle:靶向颗粒酶B分子影像探针的研究进展
- Author:
Liqin WANG
1
;
Jiangyan LIU
Author Information
1. 兰州大学第二医院核医学科,兰州 730030;兰州大学第二临床医学院,兰州 730030
- Keywords:
tumor;
immunotherapy;
granzyme B;
chemiluminescent probe;
fluorescent probe;
positron emission tomography probe
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2024;53(5):713-716
- CountryChina
- Language:Chinese
-
Abstract:
Granzyme B,as a biologically active molecule related to the cytotoxic activity of immune cells against tumors,can provide important information for the evaluation of immunotherapy efficacy in malignant tumors.Currently,related molecular probes are designed on the basis of the specific recognition sequence of granzyme B.According to different imaging principles,these probes can be divided into chemiluminescent probes,fluorescent probes,and positron emission tomography probes.All three types of probes have good targeting ability for granzyme B and real-time imaging characteristics.However,various probes also have drawbacks,such as instability in the body and susceptibility to other environmental influences.Further research is still needed to address these issues.This article summarizes the characteristics and applications of targeted granzyme B molecular probes,aiming to provide a theoretical reference for subsequent studies.
