Research progress on novel antiviral therapeutic drugs for chronic hepatitis B

VernacularTitle:慢性乙型肝炎抗病毒治疗新药研究进展
Author: Nan CAI ¹ ; Peng HU
Author Information

1. 重庆医科大学附属第二医院感染病科　感染性疾病分子生物学教育部重点实验室　重庆医科大学病毒性肝炎研究所，重庆　400010
Keywords: Chronic hepatitis B; Antiviral therapy; Functional cure; Clinical trial
From: Chinese Journal of Hepatology 2024;32(4):295-299
CountryChina
Language:Chinese
Abstract: The ideal goal of hepatitis B treatment is to achieve a functional cure, and the persistent cccDNA in the liver is a barrier to functional cure. Currently, antiviral drugs represented by pegylated interferon-α and nucleos (t) ide analogues cannot eliminate cccDNA, which is difficult to achieve functional cure. With the deepening of the exploration of various mechanisms and drug targets, significant progress has been made in the research and development of several novel drugs targeting the hepatitis B virus’s life cycle and immune system, offering hope for a functional cure. This article presents an overview of the new progress in clinical research on antiviral therapy for chronic hepatitis B based on the literature published in recent years and international conference materials.