Research progress of long-chain non-coding RNA in lipid metabolism reprogramming in primary hepatocellular carcinoma

VernacularTitle:长链非编码RNA在原发性肝细胞癌脂质代谢重编程中的研究进展
Author: Zhou YU ¹ ; Dongmei CHEN ; Jinlan HUANG
Author Information

1. 福建医科大学附属第一医院检验科　福建省检验医学重点实验室　福建医科大学基因诊断研究中心，福州　350005
Keywords: Hepatocellular carcinoma; Fatty acid; Long noncoding RNA; Lipid metabolic reprogram
From: Chinese Journal of Hepatology 2024;32(2):180-185
CountryChina
Language:Chinese
Abstract: Hepatocellular carcinoma (HCC) is the most common liver malignant tumor with complex pathogenesis and a poor prognosis. Metabolic reprogramming has been recognized as one of the important cancer markers, and the liver, as an important organ for lipid metabolism in the human body, plays an important role in the process of the occurrence and development of HCC. More and more evidence shows that long-chain non-coding RNA (lncRNA) can influence the lipid metabolism process by regulating key enzymes and transcription factors, as well as being involved in the occurrence and development of HCC. Therefore, explicating the mechanism of lncRNA in lipid metabolism reprogramming is conducive to providing new targets and strategies for the diagnosis and treatment and improving the prognosis of HCC patients. This article summarizes the latest research progress on the involvement of lncRNA in the reprogramming process of HCC lipid metabolism.