Relationship between serum inflammatory markers and prognosis of advanced non-small cell lung cancer patients treated with first-line immunosuppressants
10.11904/j.issn.1002-3070.2024.01.006
- VernacularTitle:血清炎性标志物与一线免疫抑制剂治疗晚期非小细胞肺癌患者预后的关系
- Author:
Xuan ZHANG
1
;
Xin LI
;
Kang ZHAO
Author Information
1. 哈尔滨医科大学附属肿瘤医院肿瘤内科(哈尔滨 150081)
- Keywords:
Non-small cell lung cancer;
Neutrophil-lymphocyte ratio;
Platelet count-lymphocyte ratio;
Monocyte-lympho-cyte ratio;
Pan-immune inflammatory disease value
- From:
Practical Oncology Journal
2024;38(1):37-44
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study was to explore the application of baseline neutrophil-lymphocyte ratio(NLR),platelet count-lymphocyte ratio(PLR),monocyte-lymphocyte ratio(MLR),and pan-immune inflammation value(PIV)in the use of PD-1 inhibitors combined with chemotherapy in advanced non-small cell lung cancer(NSCLC),and establish a prognosis-related nomogram model.Methods The clinical data of 77 patients with driver gene-negative advanced NSCLC who received first-line PD-1 inhibitor combined with chemotherapy at Harbin Medical University Cancer Hospital from January 2019 to January 2021 were retro-spectively analyzed.Univariate and multivariate Cox regression analysis were used to determine the independent prognostic factors of progression-free survival(PFS);A prognostic-related nomogram model was established,and the accuracy of prediction model was e-valuated through consistency index.Results Multivariate Cox regression analyses showed that MLR,PIV,brain metastasis,and pleu-ral metastasis were independent factors affecting PFS in patients with driver gene-negative advanced NSCLC(P<0.05).The nomo-gram prognostic model constructed based on the Cox regression results had a good predictive ability(C-index value was 0.786,95%CI:0.721-0.851).The ROC curve showed that the combined effect of MLR and PIV in detecting the prognosis of PFS(AUC=0.717,P=0.001)was better than that of MLR(AUC=0.643)and PIV(AUC=0.640).Conclusion MLR,PIV,brain metastasis,and pleural metastasis can predict the prognosis of driver gene-negative advanced NSCLC patients treated with first-line chemothera-py combined with PD-1 inhibitors.The established nomogram model has high accuracy and clinical practicability.The predictive per-formance of combined detection of MLR and PIV may be better than that of separate detection of MLR and PIV.
