Research progress on mechanism and treatment of intervertebral disc aging
10.3969/j.issn.1006-5725.2024.22.025
- VernacularTitle:椎间盘退行性变的机制及治疗方案研究进展
- Author:
Ji JIN
1
;
Hong SUN
;
Yong ZHUANG
;
Xu NING
;
Miao LIU
Author Information
1. 贵州医科大学附属医院骨科(贵州 贵阳 550004);贵州医科大学临床医学院(贵州 贵阳 550004)
- Keywords:
intervertebral disc degeneration;
cellular senescence;
cell aging pathways;
anti-aging cell drugs
- From:
The Journal of Practical Medicine
2024;40(22):3268-3274
- CountryChina
- Language:Chinese
-
Abstract:
Intervertebral disc degeneration(IDD)is the primary etiology of various chronic spinal disorders,characterized by clinical symptoms including low back pain and acute lower limb radicular pain.In recent years,due to accelerated population aging and lifestyle changes,there has been a significant increase in the incidence of IDD,particularly among younger individuals.This not only severely impacts patients'quality of life but also imposes substantial economic and medical burdens on society.Consequently,effective prevention and treatment strategies for IDD have become urgent medical priorities.Previous studies have demonstrated that cellular senescence of interverte-bral disc cells plays a crucial role in the initiation and progression of IDD.As such,therapeutic interventions target-ing senescent intervertebral disc cells,such as anti-senescence drugs,gene editing techniques,and stem cell therapy,are emerging as promising research areas.This review article comprehensively explores the molecular mechanisms underlying cellular senescence in IDD while discussing diverse therapeutic approaches and their latest advancements pertaining to senescent cells.The aim is to provide novel research insights and potential therapeutic targets for preventing and treating IDD while offering valuable references for future investigations.
