Impact of IgM deposition level on the ultrastructure and the clinicopathological features of primary IgA nephropathy patients
10.3969/j.issn.1006-5725.2024.22.009
- VernacularTitle:IgM沉积强度对原发性IgA肾病患者肾小球超微结构及临床病理的影响
- Author:
Lu XU
1
;
Jingjing ZHANG
;
Qiqi YAN
;
Wenting XU
;
Huai LI
;
Deguang WANG
Author Information
1. 安徽医科大学第二附属医院肾脏内科(安徽 合肥 230601)
- Keywords:
IgA nephropathy;
IgM deposition;
foot process effacement;
electron microscope
- From:
The Journal of Practical Medicine
2024;40(22):3172-3178
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlations between IgM deposition levels,glomerular ultra-structural and clinicopathological features in primary IgA nephropathy(IgAN).Methods Data from 155 IgAN patients were categorized into three cohorts by IgM deposition levels.We assessed differences in glomerular ultra-structure,clinical indices,MEST-C scores,and factors influencing IgM deposition levels.Results The marked IgM cohort showed higher urinary protein,IgG deposition,and T scores,with reduced serum albumin and lympho-cyte counts(P<0.05).Logistic regression identified FPE and T score as independent factors for IgM deposition.Conclusions IgM deposition correlates with FPE severity in IgAN,suggesting its utility in assessing renal dam-age and guiding treatment strategies.
