Metabolic study of iron deposition based on magnetic resonance in patients with nonalcoholic fatty liver disease
10.3760/cma.j.cn501113-20230902-00086
- VernacularTitle:基于MRI的非酒精性脂肪性肝病患者铁沉积的代谢研究
- Author:
Lei WANG
1
;
Huanjia QU
;
Wenjun YANG
;
Jianping DING
;
Junping SHI
;
Qiuling ZHANG
Author Information
1. 杭州师范大学附属医院重症医学科，杭州 310015
- Keywords:
Nonalcoholic fatty liver disease;
Magnetic resonance imaging;
Iron deposition;
R2*
- From:
Chinese Journal of Hepatology
2023;31(11):1204-1208
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between liver iron deposition and steatosis in patients with non-alcoholic fatty liver disease (NAFLD) through MRI.Methods:163 cases of liver biopsy underwent MRI examination. R2* was used to measure liver iron content. Dixon-based proton density fat fraction (PDFF) was used to measure liver fat content. One-way ANOVA, r-correlation, ROC curve, and others were used to assess the relationship between clinical case data, serological indices, and imaging results in accordance with the pathological results of the liver biopsy.Results:R2* gradually increased as the pathological steatosis grade rose. The R2* that corresponded to no steatosis (< 5%), mild steatosis (14.95%±8.55%), moderate steatosis (46.30%±9.32%), and severe steatosis (73.86%±6.35%) were 27.56±4.40, 31.06±5.95, 38.06±4.80, and 48.10±5.55 ( P < 0.001), respectively. There was a positive correlation between R2* and liver steatosis content ( r= 0.769, P < 0.05). The area under the ROC curve and cut-off value were 0.88 and 31.77, respectively, and there was no distinct relationship with liver inflammation or fibrosis. Conclusion:R2* can quantitatively and non-invasively evaluate liver iron deposition in patients with NAFLD. A distinct relationship exists between liver steatosis and iron deposition, and iron deposition tends to increase as the steatosis aggravates.
