Research progress on the mechanism of action of mitophagy in the occurrence and development of liver cancer

VernacularTitle:线粒体自噬在肝癌发生与发展中作用机制的研究进展
Author: Xinyu FU ¹ ; Xin ZHANG ; Keshuai DONG ; Jia YU
Author Information

1. 武汉大学人民医院肝胆外科，武汉　430060
Keywords: Hepatocellular carcinoma
From: Chinese Journal of Hepatology 2023;31(10):1113-1116
CountryChina
Language:Chinese
Abstract: Mitophagy, as an important link in maintaining mitochondrial homeostasis and environmental homeostasis in the liver, can remove damaged mitochondria and provide energy through autophagy and other processes. Additionally, it plays a dual role in the occurrence and development of liver cancer and can affect the therapeutic effect of liver cancer through a variety of signaling pathways. This article reviews the relationship between mitophagy and hepatitis B virus infection, liver cancer occurrence and development, liver cancer stem cells, mitochondrial division and fusion, therapeutic resistance and invasiveness of liver cancer, and other aspects.