Advances in oxidative stress-related pathways with diagnostic and predictive value in schizophrenia

VernacularTitle:精神分裂症中氧化应激相关通路与诊断和预测价值的研究进展
Author: Tianyue YU ¹ ; Qian GUO ; Hao HU ; Yujing SU ; Jianhua CHEN
Author Information

1. 上海交通大学医学院附属精神卫生中心,上海市精神卫生中心(上海 200030)
Keywords: oxidative stress; inflammatory factor; schizophrenia; biomarker
From: The Journal of Practical Medicine 2024;40(20):2935-2940
CountryChina
Language:Chinese
Abstract: Schizophrenia is a severe mental illness with a significant disease burden.The interaction between oxidative stress and pro-inflammatory factors promotes chronic neuroinflammation and immune damage,leads to dysregulation of dopaminergic and glutamatergic pathways and occurrence of psychotic symptoms and is believed to be closely related to the pathogenesis of schizophrenia.In this paper,we aim to identify biomarkers within the tryptophan kynurenine metabolic pathway,the WNT/β-Catenin pathway and the NF-κB pathway,and dopamine metabolism.These pathways have been extensively studied and are known to be involved in the interac-tion between inflammation and oxidative stress.We will also explore the potential application of related antioxidants in the diagnosis and treatment of schizophrenia,summarizing their current research progress.