Effect of the nomenclature of non-alcoholic fatty liver disease on diagnosis and treatment of fatty liver disease concomitant with other liver diseases
10.3760/cma.j.cn501113-20230810-0050
- VernacularTitle:非酒精性脂肪性肝病更名对脂肪肝合并其他肝病诊治的影响
- Author:
Lin CHEN
1
;
Lina JIANG
;
Jingmin ZHAO
Author Information
1. 解放军总医院第五医学中心病理科，北京 100039
- Keywords:
Fatty liver disease;
Non-alcoholic fatty liver disease;
Metabolic associated fatty liver disease/Metabolic dysfunction-associated steatotic liver diseas
- From:
Chinese Journal of Hepatology
2023;31(8):805-809
- CountryChina
- Language:Chinese
-
Abstract:
Fatty liver disease (FLD) is one of the major causes of chronic liver disease worldwide. With the increasing incidence of obesity and metabolic syndrome worldwide, FLD concomitant with other liver diseases is becoming more common, and multiple etiological overlap is associated with poor disease prognosis. Therefore, FLD concomitant with other liver diseases is a clinical concerning issue. Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of disease continuum from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), and relative end stage liver disease, excluding other factors that may lead to fatty liver disease such as excessive alcohol consumption et. al. Following the nomenclature of NAFLD with metabolic associated fatty liver disease (MAFLD), an international panel of experts proposed a new name in June 2023 as Metabolic dysfunction - associated steatotic liver disease (MASLD), replacing the word "fatty" with "steatotic," The effect of lipid toxicity on FLD progression was highlighted. Compared with the concept of MAFLD, the disease spectrum of MASLD is broader, and the etiology and mechanism are more clear. The nomenclature of FLD brings some influence to the diagnosis and treatment of chronic liver diseases concomitant with FLD, including chronic hepatitis B, alcoholic fatty liver disease and genetic metabolic diseases. This article reviews the influence of renaming FLD on the diagnosis and treatment of FLD concomitant with other etiologies caused liver diseases.
