Research advance on long non-coding RNA regulating myeloid-derived suppressor cells in tumors
10.3969/j.issn.1006-5725.2024.18.024
- VernacularTitle:长链非编码RNA参与调控肿瘤中髓源性抑制细胞的研究进展
- Author:
Kengjun LUO
1
;
Wenbo ZHANG
;
Pengcheng JIANG
Author Information
1. 江苏大学附属人民医院普外科(江苏镇江 212002)
- Keywords:
lncRNA;
MDSCs;
tumor;
TME;
tumor immunity
- From:
The Journal of Practical Medicine
2024;40(18):2647-2653
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNAs(lncRNAs),a group of non-coding RNAs with lengths exceeding 200 nucleotides,play a crucial role in the human transcriptome,particularly in various types of cancers,where they are pivotal in regulating the tumor immune microenvironment and tumor cell immune evasion.However,there is currently a lack of systematic literature review.Myeloid-derived suppressor cells(MDSCs),a subset of myeloid cells with immunosuppressive functions,play a significant role in cancer by directly and indirectly suppressing T cell activity,promoting the expansion of regulatory T cells,modulating the tumor microenvironment,and facilitating tumor metastasis.This review emphasizes the importance of in-depth investigation into the regulatory mechanisms of MDSCs for the discovery of effective tumor therapeutic targets and the development of novel treatment strategies.With further understanding and research into the relationship between lncRNAs and MDSCs,it is anticipated that more targets and new therapeutic approaches will be identified for cancer treatment,thereby improving clinical outcomes for patients.
