Progress in basic research and clinical application of hepatocyte transplantation
10.3760/cma.j.cn501113-20210402-00160
- VernacularTitle:肝细胞移植的基础研究及临床应用进展
- Author:
Guangpeng ZHOU
1
;
Zhijun ZHU
;
Liying SUN
Author Information
1. 首都医科大学附属北京友谊医院肝脏移植中心 首都医科大学儿童肝脏移植临床诊疗与研究中心 国家消化系统疾病临床医学研究中心，北京 101100
- Keywords:
Hepatocyte transplantation;
Acute liver failure;
Inherited metabolic liver disease
- From:
Chinese Journal of Hepatology
2023;31(2):216-220
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocyte transplantation is considered a promising alternative treatment to liver transplantation. Although the safety and efficacy of hepatocyte transplantation in the treatment of acute liver failure and certain inherited metabolic diseases of the liver have been validated in many clinical trials, clinical hepatocyte transplantation still faces many problems and limitations, such as a shortage of high-quality donor organs, reduced cell viability after cryopreservation, low cell implantation and proliferation rates, and allogeneic hepatocyte rejection. This article reviews the latest basic research and clinical application progress in hepatocyte transplantation.
