The pathogenesis and potential therapeutic targets of metaflammation in NAFLD
10.3969/j.issn.1006-5725.2024.18.003
- VernacularTitle:代谢性炎症新概念及其与非酒精性脂肪性肝病发病机制和治疗靶点的联系
- Author:
Chunyan NIU
1
;
Jiankang HUANG
Author Information
1. 南京市溧水区人民医院消化内科(南京 211200)
- Keywords:
metaflammation;
NAFLD;
inflammatory molecules;
inflammatory pathways;
targeted drugs
- From:
The Journal of Practical Medicine
2024;40(18):2525-2529
- CountryChina
- Language:Chinese
-
Abstract:
"Metaflammation,"proposed by Hotamisligil in 2006,refers to a chronic low-grade inflamma-tion triggered by metabolic factors such as excessive nutrition and energy,persisting at subacute levels over an extended period.Immune cells infiltrate the inflammatory site,leading to enhanced expression or activity of various inflammatory molecules and subsequent inflammatory damage.Recent research on metabolic-related fatty liver disease has revealed that modern metaflammation plays a pivotal role in the pathogenesis of NAFLD.The associated inflammatory pathways offer promising prospects for the development of targeted drugs.This article provides an updated review on the advancements in metaflammation within NAFLD.
