Regulatory mechanism and potential value of circular RNA in nonalcoholic fatty liver disease progression
10.3760/cma.j.cn501113-20220827-00444
- VernacularTitle:环状RNA在非酒精性脂肪性肝病进展中的调控机制及潜在价值
- Author:
Qun XIE
1
;
Lingling WANG
;
Li WANG
;
Dengfu YAO
;
Min YAO
Author Information
1. 南通大学附属医院临床医学研究中心，南通 226001
- Keywords:
Non-alcoholic fatty liver disease;
Mechanism;
Potential clinical values;
Circular RNA
- From:
Chinese Journal of Hepatology
2022;30(11):1270-1275
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease (nonalcoholic?fatty?liver?disease, NAFLD) or metabolic-associated fatty liver disease, has become the most common chronic liver disease worldwide. In recent years, the relationship between NAFLD and non-coding RNA (ncRNA) has attracted the attention of basic and clinical researchers. Circular RNA (circRNA) is a lipid metabolism-related non-coding RNA (ncRNA) that is highly conserved in eukaryotic cells and resembles but differs from linear ncRNAs at their 5'- and 3'-terminal ends. With tissue-specific and steady expression of endogenous ncRNA, miRNA binding sites are contained on closed and circular nucleoside chains, forming the circRNA-miR-mRNA axis or network with proteins, competing with endogenous RNA sponge-like mechanisms, playing a role in inhibiting or promoting the expression of related target genes, and participating in the progression of NAFLD. This paper reviews the circRNA regulatory mechanism, detection technology, and potential clinical value in NAFLD.
