Correlation between serum levels of miR-23a,miR-150,and miR-150-5p and diabetic osteoporosis
10.3969/j.issn.1006-5725.2024.16.008
- VernacularTitle:血清miR-23a、miR-150、miR-150-5p水平与糖尿病性骨质疏松症的相关性
- Author:
Xiaoli SUN
1
;
Huijie FAN
Author Information
1. 河南中医药大学第五临床医学院(郑州人民医院)内分泌科(郑州 450000)
- Keywords:
diabetes;
osteoporosis;
microRNA-23a;
microRNA-150;
microRNA-150-5p
- From:
The Journal of Practical Medicine
2024;40(16):2244-2249
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between microRNA(miR)-23a,miR-150,and miR-150-5p levels and diabetic osteoporosis(DOP)through correlation analysis.Methods A total of 200 patients with diabetes who visited the hospital between March 2020 and March 2022 were selected and followed up for a duration of 2 years.Patients who developed DOP and those who did not were respectively assigned to the DOP group and the non-DOP group.The general information and serum levels of miR-23a,miR-150,and miR-150-5p between these two groups were compared.Pearson correlation analysis was conducted to examine the relationship between serum levels of miR-23a,miR-150,and miR-150-5p,as well as bone density.Logistic regression model was employed to identify factors influencing DOP.Results The incidence rate of DOP was 28.89%.The serum levels of miR-23a,miR-150,and miR-150-5p were significantly elevated in the DOP group compared to the non-DOP group(P＜0.05).Pearson correlation analysis revealed a negative association between the serum levels of miR-23a,miR-150,and miR-150-5p in diabetic patients and bone density(P＜0.05).Logistic regression model analysis demonstrated that age,body mass index(BMI),as well as miR-23a,miR-150,and miR-150-5p were influential factors contributing to the development of DOP(P＜0.05).Conclusion The levels of serum miR-23a,miR-150,and miR-150-5p are elevated in patients with DOP,and all three exhibit a negative correlation with bone density.Furthermore,these factors collectively contribute to the development of DOP.
