Progress in the clinical treatment of alcoholic hepatitis
10.3760/cma.j.cn501113-20210102-00003
- VernacularTitle:酒精性肝炎临床治疗进展
- Author:
Lulu LIU
1
;
Jing TONG
;
Bingyuan WANG
Author Information
1. 湖北文理学院附属医院 襄阳市中心医院消化内科，襄阳 441021
- Keywords:
Alcoholic hepatitis;
Therapeutic;
Corticosteroid;
Liver transplantation
- From:
Chinese Journal of Hepatology
2022;30(6):672-675
- CountryChina
- Language:Chinese
-
Abstract:
Alcoholic hepatitis is a severe and life-threatening systemic inflammatory response syndrome, which has a high incidence and mortality rate worldwide. The severity ranges from asymptomatic liver biochemical disturbances to fulminant liver failure or death; however, there are few effective therapeutic interventions. Maddrey discriminant function not only predicts short-term mortality, but it also guides clinicians to choose appropriate alcoholic hepatitis-specific treatments. Alcohol abstinence, nutritional support, psychological counseling, and infection prevention remain the cornerstones for alcoholic hepatitis treatment. Corticosteroids remain the mainstay of treatment when patients have a good appetite and normal serum creatinine levels, but early liver transplantation is the only life-saving option for steroid-unresponsive patients. New studies have found that gut microbiota is an important therapeutic targets in patients with alcohol hepatitis, and N-acetylcysteine, granulocyte colony-stimulating factor, and metadoxine as adjunctive therapy have a positive effect on patient survival.
