Clinical significance and management strategies of low-level viremia during the treatment of chronic hepatitis B
10.3760/cma.j.cn501113-20211122-00567
- VernacularTitle:慢性乙型肝炎治疗过程中低病毒血症的临床意义和管理策略
- Author:
Ning HAN
1
;
Libo YAN
;
Hong TANG
Author Information
1. 四川大学华西医院感染性疾病中心 四川大学生物治疗国家重点实验室感染性疾病研究室，成都 610041
- Keywords:
Chronic hepatitis B;
Low-level viremia;
Nucleos(t)ide analogs;
Antiviral therapy
- From:
Chinese Journal of Hepatology
2021;29(12):1139-1143
- CountryChina
- Language:Chinese
-
Abstract:
Chronic hepatitis B and its related complications seriously endanger the lives and health of our country people. Although the first-line nucleos(t)ide analogs such as entecavir, tenofovir disoproxil fumarate and tenofovir alafenamide fumarate can inhibit virus replication to a certain extent, delay or prevent disease progression, and reduce the incidence of hepatitis B-related liver cancer, but in clinical practice, HBV DNA positivity is still detected continuously or intermittently in the serum of some patients. Therefore, low-level viremia has received widespread attention and triggered discussion, and has become the difficulties and hotspot of antiviral treatment of chronic hepatitis B. This article summarizes and discusses the definition and incidence in line with the main guidelines and studies, impact of disease control and clinical prognosis, and the current treatment options in order to provide definite reference for the management of low-level viremia during antiviral therapy in patients with chronic hepatitis B.
