Research progress on relationship between cellular senescence and scar fibrosis
10.3969/j.issn.1006-5725.2024.12.023
- VernacularTitle:细胞衰老与瘢痕纤维化的关系研究进展
- Author:
Jingwen AN
1
;
Jun-Yun FENG
;
Lei RAO
;
Dewu LIU
Author Information
1. 南昌大学第一附属医院烧伤整形与创面修复医学中心(南昌 330006)
- Keywords:
cellular senescence;
fibrosis of scar;
targeted therapy
- From:
The Journal of Practical Medicine
2024;40(12):1749-1754
- CountryChina
- Language:Chinese
-
Abstract:
Cellular senescence and fibrosis are two biological processes that are closely related to the development of many diseases.Cellular senescence can occur through mechanisms such as telomere shortening,DNA damage,and oxidative stress,leading to degradation of cell function and decreased ability to repair damage.More and more studies have shown that fibrosis and cell senescence are closely related,and cell senescence has been confirmed to be involved in the occurrence and development of scar fibrosis diseases.An in-depth understand-ing of the relationship between cellular senescence and scar fibrosis is helpful to find new therapeutic strategies and develop targeted drugs to reduce the process of scar fibrosis.
