The pathogenesis of ischemic hepatitis

VernacularTitle:缺血性肝炎的相关发病机制
Author: Zhonglin LI ¹ ; Weijun WANG ; Ling YANG
Author Information

1. 华中科技大学同济医学院附属协和医院消化内科，武汉　430022
Keywords: Hepatitis; Ischemic hepatitis; Hepatic ischemia hypoxia injury; Hepatic ischemia reperfusion injury
From: Chinese Journal of Hepatology 2021;29(7):705-710
CountryChina
Language:Chinese
Abstract: Ischemic hepatitis is inflammation caused by necrosis of liver cells due to ischemia and hypoxia caused by low cardiac output or septic shock. It is often complicated by heart failure or severe septic shock. One of the pathogenesis of ischemic hepatitis is hepatocyte injury caused by ischemia and hypoxia, which results in damage-associated molecular patterns (DAMPs) release and binding to membrane receptors such as toll like receptors (TLRs) to cause inflammatory reactions.The other is when the ischemic liver is reperfused, hepatocyte mitochondrias will produce a large amount of ROS causing ischemia reperfusion injury. These two mechanisms and related molecular pathways are elaborated in this paper.