Impact of serum vitamin A levels on all-cause mortality risk in diabetes patients:a prospective study
10.16753/j.cnki.1008-2344.2024.06.004
- VernacularTitle:血清维生素A水平对糖尿病患者死亡风险的影响:一项前瞻性研究
- Author:
Zhuo LI
1
;
Baoyuan JIANG
;
Yu OUYANG
;
Yaxin XIANG
;
Zhen YANG
;
Lianying GUO
Author Information
1. 北京卫戍区海淀第三十四离职干部休养所门诊部,北京 100083
- Keywords:
vitamin A;
diabetes;
mortality risk
- From:
Journal of Shenyang Medical College
2024;26(6):575-581
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the impact of serum vitamin A levels on all-cause mortality risk in diabetes patients.Methods:Diabetes patients aged 20 years and above who participated in the US National Health and Nutrition Examination Survey during 2003-2004 and 2005-2006 were enrolled as the study population,with death data up to 2019 as the endpoint.Cox proportional hazards regression models were employed to calculate the hazard ratios of all-cause mortality in diabetes patients with different serum vitamin A levels,both unadjusted and adjusted for confounders.Restricted cubic spline methods were used to analyze the dose-response relationship between serum vitamin A levels and all-cause mortality risk in diabetes patients.Results:A total of 484 diabetes patients were included,with a median follow-up period of 13.7 years,during which 211 deaths occurred.Cox proportional hazards analysis showed that compared to the lowest quartile of serum vitamin A,higher quartiles of serum vitamin A were not associated with all-cause mortality risk in diabetes patients without adjusting for confounders.However,after adjusting for confounders,higher quartiles of serum vitamin A significantly reduced the all-cause mortality risk.The dose-response analysis indicated a significantly increased risk of all-cause mortality in diabetes patients with lower serum vitamin A levels.As the vitamin A levels increased,the mortality risk gradually decreased.A significant reduction in all-cause mortality risk was observed when serum vitamin A levels were between 2.17 and 2.50 μmol/L.Beyond this range,there was a tendency for increased all-cause mortality risk with further increases in vitamin A levels.Conclusion:Lower serum vitamin A levels increase the all-cause mortality risk in diabetes patients,while moderate serum vitamin A levels help reduce the all-cause mortality risk in diabetes patients.
