New insights into immunotolerant phase of chronic hepatitis B virus infection
10.3760/cma.j.cn501113-20200629-00352
- VernacularTitle:慢性乙型肝炎病毒感染免疫耐受期的新认识
- Author:
Menghui DUAN
1
;
Xueen LIU
;
Hui ZHUANG
Author Information
1. 北京大学医学部基础医学院病原生物学系和感染病中心 100191
- Keywords:
Hepatitis B virus;
Chronic hepatitis B;
Hepatocellular carcinoma;
Liver fibrosis;
Immune tolerance
- From:
Chinese Journal of Hepatology
2021;29(3):284-288
- CountryChina
- Language:Chinese
-
Abstract:
Patients in "immunotolerant phase" of chronic hepatitis B virus infection are HBsAg and HBeAg-positive, with high HBV DNA level, normal ALT and no obvious histopathological hepatic necrotizing inflammation or fibrosis. However, in recent years, some studies have found that HBV DNA integration, clonal hepatocyte expansion, HBV-specific T cell immune response, liver injury and disease progression exist in patients with "immunotolerant phase" of chronic HBV infection. Therefore, the concept of "immunotolerant phase" is controversial. This paper summarizes the new insights into the "immunotolerant phase" of chronic hepatitis B virus infection, including its new concepts in nomenclature, diagnosis, treatment and management.
