Metabolism and transport pathway of prostaglandin E2 and its role in liver regeneration
10.3760/cma.j.cn501113-20190422-00140
- VernacularTitle:前列腺素E2的代谢和转运途径及其在肝再生中的作用
- Author:
Ning YANG
1
;
Guodong LYU
;
Hao WEN
Author Information
1. 新疆医科大学第一附属医院临床医学研究院省部共建中亚高发病成因与防治国家重点实验室，乌鲁木齐 830011
- Keywords:
Prostaglandin E2;
Liver regeneration;
Metabolic pathway;
Signaling pathway
- From:
Chinese Journal of Hepatology
2021;29(2):183-187
- CountryChina
- Language:Chinese
-
Abstract:
The liver is an organ with regenerative capacity and is essential for maintaining the body homeostasis. Under pathological conditions, such as chronic hepatitis, liver cirrhosis and so on, the impairment of liver regeneration can lead to insufficient liver function or even liver failure. Therefore, promoting liver regeneration can improve the patient's prognosis. Prostaglandin E2 is a hormone-like messenger with physiological activity that can promote tissue regeneration. This article reviews the metabolism and transport pathways of prostaglandin E2 and its mechanism of action in liver tissue regeneration, and proposes that prostaglandin E2 is an important cytokine involved in the liver regeneration process, and has potential clinical application prospects for the treatment of liver injury.
