Longitudinal study of symptom cluster and quality of life in young and middle-aged postoperative patients with cervical cancer during chemotherapy
10.3760/cma.j.cn211501-20240224-00409
- VernacularTitle:中青年宫颈癌术后患者化疗期间症状群与生命质量的纵向研究
- Author:
Yuan HU
1
;
Hongmei ZHANG
;
Jinfeng LI
;
Huijuan ZHANG
;
Huimeng ZHANG
Author Information
1. 河南省人民医院 郑州大学人民医院妇科，郑州 450000
- Keywords:
Uterine cervical neoplasms;
Young and middle-aged;
Chemotherapy;
Symptom clusters;
Quality of life;
Longitudinal study
- From:
Chinese Journal of Practical Nursing
2024;40(32):2503-2512
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the longitudinal changes of symptom clusters and quality of life in young and middle-aged postoperative patients with cervical cancer during chemotherapy, and to clarify the correlation between the two, in order to provide reference for clinical staff symptom management and improvement of patients′ quality of life.Methods:A longitudinal study was conducted, a total of 252 young and middle-aged who underwent chemotherapy after radical cervical cancer surgery in the gynecological ward of Henan Provincial People′s Hospital from December 2022 to August 2023 were selected as the investigation objects by convenient sampling method. Data were collected at 2 d before chemotherapy (T1), 1 week after the first chemotherapy (T2), 1 week after the third chemotherapy (T3), and 1 week after the sixth chemotherapy (T4), using the general data questionnaire, the Chinese version of the Memorial Symptom Assessment Scale and the Functional Assessment of Cancer Therapy-Cervix. Exploratory factor analysis was used to extract symptom clusters from the data. The generalized estimation equation model was used to analyze the dynamic change trend and correlation between symptom clusters and quality of life.Results:A total of 221 patients with cervical cancer aged 18-59 (46.85 ± 6.50) years old were included. At T1 and T2, there were 4 symptom clusters, which were psychological symptom cluster, gastrointestinal symptom cluster, disease behavior symptom cluster and perimenopausal symptom cluster. T3 and T4 increased the neurological symptom cluster and self-image disorder symptom cluster, a total of 6 symptom clusters. The higher score of each symptom cluster, the lower total score of quality of life (Wald χ2 values were 8.08-62.70, all P<0.01). Conclusions:Young and middle-aged postoperative patients with cervical cancer suffered from multiple symptom clusters during chemotherapy, which not only remained relatively stable, but also showed a constantly changing trend. Effective dynamic management of symptoms clusters in young and middle-aged postoperative patients with cervical cancer during chemotherapy is expected to improve their quality of life.
