Research progress of single-nucleotide polymorphism in theTM6SF2 rs58542926
10.3760/cma.j.issn.1007-3418.2019.03.012
- VernacularTitle:跨膜6超家族成员2 rs58542926单核苷酸多态性的研究进展
- Author:
Yuan LI
1
;
Xin SUN
;
Shuhui ZHAN
;
Yuqiang GAO
;
Yongning XIN
;
Shiying XUAN
Author Information
1. 青岛市市立医院消化科 266000
- Keywords:
Single nucleotide polymorphisms;
Fatty liver,nonalcoholic;
Blood lipids;
Transmembrane 6 superfamily members 2
- From:
Chinese Journal of Hepatology
2019;27(3):223-226
- CountryChina
- Language:Chinese
-
Abstract:
Transmembrane 6 superfamily member 2 (TM6SF2) is a recently discovered gene,which is located on the chromosome 19 (19p12) and encodes a protein consisting of 351 amino acids.Presently,many studies have reported that the single-nucleotide polymorphism of TM6SF2 rs58542926 and plasma lipids are closely related to the incidence and development of diseases,such as non-alcoholic fatty liver disease (NAFLD),cardiovascular disease (CVD),liver cancer,and hepatitis C.This review will summarize the research progress conducted in these areas.
