The relationship of serum miR-124,miR-134 and CT regional assessment grading of pia mater collateral,core infarct volume and prognosis in patients with acute ischemic stroke
10.3969/j.issn.1002-1671.2024.12.002
- VernacularTitle:急性缺血性脑卒中患者血清miR-124、miR-134和CT区域软脑膜侧支评估分级与核心梗死体积、预后的关系
- Author:
Yiqiang WANG
1
;
Dongxin YANG
Author Information
1. 辽宁省健康产业集团抚矿总医院放射科,辽宁 抚顺 312000
- Keywords:
CT regional pia mater collateral score;
miR-124;
miR-134;
acute ischemic stroke
- From:
Journal of Practical Radiology
2024;40(12):1941-1944,1948
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of serum micro ribonucleic acid(miR)-124,miR-134 and CT regional assessment grading of pia mater collateral,core infarct volume and prognosis in patients with acute ischemic stroke.Methods A total of 192 patients with acute ischemic stroke(observation group)and 100 healthy volunteers(control group)were selected.The serum miR-124 and miR-134 were compared between the two groups.At the same time,the serum miR-124,miR-134 and the score of pia mater collateral in CT region of patients with different clinical characteristics in the observation group were analyzed.Results The relative expression levels of serum miR-124 and miR-134 in the observation group were significantly higher than those in the control group(P＜0.05).The relative expression serum miR-124 and miR-134 in patients with core infarct volume≥50 mL in the observation group were significantly higher than those in patients with core infarct volume＜50 mL(P＜0.05).In the observation group,the score of pia mater collateral in CT region of patients with core infarct volume ≥50 mL was significantly lower than that of patients with core infarct volume＜50 mL(P＜0.05).The relative expression levels of serum miR-124 and miR-134 were positively correlated with the core infarct volume(r=0.378 and 0.466,P＜0.05),and the score of pia mater collateral in CT region was negatively correlated with the core infarct volume(r=-0.463,P＜0.05).The relative expression levels of serum miR-124 and miR-134 in patients with poor prognosis were significantly higher than those in patients with good prognosis(P＜0.05),while the score of pia mater collateral in CT region was significantly lower than that in patients with good prognosis(P＜0.05).Conclusion The serum miR-124 and miR-134 in patients with acute ischemic stroke are up-regulated,and miR-124 and miR-134 are positively correlated with the core infarct volume,while the score of pia mater collateral in CT region is negatively correlated with the core infarct volume.At the same time,miR-124,miR-134,and the score of pia mater collateral in CT region may be related to the prognosis of patients.
