The value of radiomics based on ADC and DCE-MRI in the differential diagnosis between non-puerperal mastitis and non-mass breast cancer
10.3969/j.issn.1002-1671.2024.10.013
- VernacularTitle:基于ADC和DCE-MRI影像组学对非哺乳期乳腺炎与非肿块型乳腺癌鉴别诊断的价值
- Author:
Zhuyuan HUANG
1
;
Xin LIN
;
Xingyu CHEN
;
Rui YAN
Author Information
1. 西北妇女儿童医院医学影像中心,陕西 西安 710061
- Keywords:
non-puerperal mastitis;
non-mass breast cancer;
radiomics;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2024;40(10):1636-1640
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the differential diagnosis value between non-puerperal mastitis(NPM)and non-mass breast cancer by radiomics based on apparent diffusion coefficient(ADC)and dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI).Methods The clinical data,ADC and DCE-MRI imaging data of 27 patients with NPM and 66 patients with non-mass breast cancer confirmed by pathology were analyzed retrospectively.By using 3D Slicer software,the region of interest(ROI)of the lesion was delineated layer by layer,and then the PyRadiomics package was used to extract the radiomics features.The feature variables were screened out by using least absolute shrinkage and selection operator(LASSO)regression,and recursive feature elimination(RFE)methods.The classification model was constructed by using leave-one-out cross validation and logistic regression(LR).The differential diagnostic value was analyzed by using the receiver operating characteristic(ROC)curve.Results The sensitivity,specificity and area under the curve(AUC)of the combined ADC and DCE-MRI radiomics model were 0.985,0.815 and 0.979,respectively.The sensitivity,specificity,and AUC of the radiologist were 0.788,0.667,and 0.727,respectively.There was significant difference in AUC between the two groups(P＜0.05).Conclusion The radiomic model combined ADC and DCE-MRI is expected to be a reliable auxiliary method to distinguish NPM from non-mass breast cancer,because of higher sensitivity and specificity than radiologist.
