Relationship between MRI imaging findings of invasive prostate cancer and serum miR-27a and AMACR levels and its prognostic analysis
10.3969/j.issn.1002-1671.2024.09.019
- VernacularTitle:侵袭性前列腺癌MRI影像表现与血清miR-27a、AMACR水平的关系及其预后分析
- Author:
Ze SONG
1
;
Jing LI
;
Gang HUANG
Author Information
1. 河西学院医学院影像教研室,甘肃 张掖 734000
- Keywords:
prostate cancer;
magnetic resonance imaging;
miR-27a;
alpha-methylacyl-CoA racemase;
prognosis
- From:
Journal of Practical Radiology
2024;40(9):1480-1483
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between MRI imaging findings of invasive prostate cancer and serum miR-27a and alpha-methylacyl-CoA racemase(AMACR)levels and its prognostic analysis.Methods A total of 112 patients with prostate cancer were divided into middle-low risk group(n=61)and high-risk group(n=51)according to the results of postoperative pathological grading.All patients underwent MRI and serum miR-27a and AMACR examinations within 1 week before surgery.Spearman rank correlation was used to analyze the correlation between MRI imaging findings and serum miR-27a and AMACR levels in the two groups.All patients were followed up for more than 24 months after surgery,and the prognosis of the two groups was analyzed.Results Compared with the middle-low risk group,the apparent diffusion coefficient(ADC)value in the high-risk group was lower,and the Ktrans and Kep were higher(P＜0.05).Compared with the middle-low risk group,the serum miR-27a and AMACR levels in the high-risk group were higher(P＜0.05).Spearman rank correlation analysis showed that ADC value was negatively correlated with serum miR-27a and AMACR levels(P＜0.05),and Kep and Ktrans were positively correlated with serum miR-27a and AMACR levels(P＜0.05).The patients with recurrence and metastasis in the high-risk group were significantly more than those in the middle-low risk group(P＜0.05).Conclusion MRI imaging findings and serum miR-27a and AMACR levels can be used to evaluate the invasiveness and prognosis of prostate cancer.
