MRI study of cortical structure in adolescents with major depression disorder
10.3969/j.issn.1002-1671.2024.06.002
- VernacularTitle:青少年重度抑郁症MRI脑皮层结构研究
- Author:
Jun WU
1
;
Liping REN
;
Gaofeng ZHANG
Author Information
1. 遵义医科大学第二附属医院影像科,贵州 遵义 563000
- Keywords:
adolescent;
major depression disorder;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2024;40(6):866-869
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the abnormal brain regions in morphology and its correlation with clinical symptoms of adolescents with major depression disorder.Methods Forty adolescents patients with major depression disorder were enrolled as the case group,and 30 healthy volunteers were recruited as the control group(age,gender,education level and handedness matched with the case group).Depressive symptoms in both groups were assessed by the 17-item Hamilton depression scale(HAMD-17).3D-T1 WI imaging data were acquired by GE 3.0T MR for the two groups.Freesurfer software was used to analyze the cortical thickness(CT)and surface area(SA)values of whole brain of the two groups.Two-sample independent t-test statistical analysis was used to analyze the differences of the values of the whole brain CT,SA between the two groups.Pearson correlation analysis was used to analyze the correlation between abnormal CT,SA values and HAMD-17 score in case group.P＜0.05 was considered statistically significant.Results There were no statistically significant differences in gender,age,education level,origin of students and interests between the two groups(P＞0.05),while there was statistically significant difference in HAMD-17 score between the two groups(P＜0.05).The average course of disease in the case group was(14.84+2.71)months,and both groups were right-handed.Brain CT value increased in right medial orbitofrontal lobe and decreased in left anterior central gyrus in case group.There was no difference in the value of SA between the two groups(P＞0.05).Pearson correlation analysis showed that the CT value of right medial orbitofrontal lobe was positively correlated with HAMD-17 score.Conclusion It is abnormal for the CT of partial brain regions of adolescents with major depression disorder,but the SA hadn't change significantly.The right medial orbitofrontal lobe has important significance on adolescent depression symptoms.
