Effects of intestinal endotoxemia on pathogenesis of liver injury induced by thioacetamide

VernacularTitle:肠源性内毒素血症在硫代乙酰胺所致肝损伤发病中的作用
Author: Lixin LIU ¹ ; Dewu HAN ; Dabin REN
Author Information

1. 山西医科大学
Keywords: Thioacetamide; Endotoxins; Toxemia; Liver injury
From: Chinese Journal of Hepatology 2000;8(3):174-175
CountryChina
Language:Chinese
Abstract: Objective To study the effect of intestinal endotoxemia on pathogenesis of liver injury induced by thioacetamide(TAA). Methods Twenty-six male Wistar rats were divided into 4 groups, namely: normally control group (N), colectomy control group(C), colectomy+TAA group(C+T), TAA group(T). The changes in plasma biochemistry were measured. Results Plasma endotoxin levels were significantly higher in TAA group than normally control group. Plasma endotoxin levels in colectomy+TAA group were close to that of normally control group. Plasma ALT activity in colectomy+TAA group increased significantly compared with that of normal control group, but markedly lower than that in TAA group. Plasma endotoxin levels were positively correlated to ALT activity in T and C+T groups(r=0.985, P<0.01). Conclusion TAA itself has a deleterious effect to hepatic cells. It can also induce intestinal endotoxemia in which the liver injury is more inclined to occur and severe.