Study on the resting state functional connectivity of the brain network in cervical discogenic pain
10.3969/j.issn.1002-1671.2024.05.002
- VernacularTitle:颈椎间盘源性疼痛相关脑网络静息态功能连接研究
- Author:
Hong ZHANG
1
;
Xiaoping WU
;
Ming GAO
;
Run LIU
;
Xiaohui YIN
;
Song CHEN
;
Mingyue MA
Author Information
1. 西安交通大学附属西安市中心医院放射科,陕西 西安 710003
- Keywords:
cervical discogenic pain;
pain network;
functional connectivity;
resting-state functional magnetic resonance imaging
- From:
Journal of Practical Radiology
2024;40(5):693-696
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the abnormal changes of resting state functional connectivity of pain networks in patients with cervical discogenic pain(CDP).Methods The resting-state functional magnetic resonance imaging(rs-fMRI)data of 40 patients with CDP and 40 age-and gender-matched healthy controls(HC)were collected.The seed of posterior insula(PI)was used to define the pain network,and seed-based whole-brain functional connectivity analyses were performed to explore the difference of functional connectivity between CDP patients and HC,the associations between functional connectivity and clinical measures were analyzed.Results The functional connectivity between bilateral PI and bilateral thalamus(THA)was increased,and the functional connectivity between left PI and middle cingulate cortex(MCC),left postcentral gyrus(PoCG)and MCC were decreased in CDP patients.Moreover,the func-tional connectivity between right PI and left THA was positively correlated with visual analogue scale(VAS),and the functional connectivity between left PoCG and MCC was negatively correlated with VAS.Conclusion Functional connectivity abnormalities exist in pain network resting state of CDP patients,which may provide an imaging basis for revealing the neuropathological mechanism of pain in CDP patients.
