Clinical analysis of 15 patients with epileptic spasms and focal seizures as a single ictal event in neonatal period
10.3760/cma.j.cn112140-20210324-00252
- VernacularTitle:新生儿期一次发作事件中癫痫性痉挛与局灶性发作共存15例临床分析
- Author:
Yan XU
1
;
Xinran DONG
;
Peng ZHANG
;
Xinhua WANG
;
Yuanfeng ZHOU
;
Guoqiang CHENG
Author Information
1. 国家儿童医学中心 复旦大学附属儿科医院神经内科 201102
- Keywords:
Seizures;
Spasm;
Focal seizures;
Infant, newborn
- From:
Chinese Journal of Pediatrics
2021;59(12):1055-1058
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the phenomenon of epileptic spasms (ES) and focal seizures (FS) in a single ictal event (FS-ES phenomenon) and to study the etiology, manifestations, and prognosis of this phenomenon.Methods:The data of the 15 neonates who had ES and FS in a single ictal event, according to video-electroencephalography (VEEG) recording in Department of Neonatology of Children′s Hospital of Fudan University during the period of January 2018 to December 2019, was analyzed retrospectively.Results:Of the 15 neonates, 7 were male and 8 were female. Gestational age was 39 (32-42) weeks. Birth weight was 3 100 (1 825-3 850) g. The initial onset age of convulsions was 2 (1-10) days. The age of the first discovery of FS-ES phenomenon was 25 (14-32) days. The age of seizure-free was 7(1-27) months. All of the initial seizure types were FS. The FS-ES phenomenon of 15 patients started with FS. The FS-ES phenomenon manifested in 2 forms: FS followed by ES (12 cases), ES appeared during an FS without interrupting FS (2 cases). In 1 neonate the spasm occurred in both forms. The etiology included genetic factors (9 cases), intracranial infection (1 case), abnormal brain tissue structure (2 cases), and etiology was unknown in 3 cases. All the neonates had a poor prognosis except one.Conclusions:The FS-ES phenomenon in the neonatal period starts with FS. There are various etiologies. Etiologies of most patients are genetic factors. Most of the patients have a poor prognosis.
