Changes of Serum FIZZ2 and IL-33 Levels in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease and Their Correlation with Clinical Prognosis
10.3969/j.issn.1671-7414.2024.05.026
- VernacularTitle:慢性阻塞性肺疾病急性加重期患者血清FIZZ2和IL-33水平变化与临床预后的相关性研究
- Author:
Jiaming WU
1
;
Yun LIU
;
Dewei ZHOU
Author Information
1. 中国科学院合肥肿瘤医院呼吸内科,合肥 230088
- Keywords:
chronic obstructive pulmonary disease;
found in inflammatory zone 2;
interleukin-33
- From:
Journal of Modern Laboratory Medicine
2024;39(5):140-145
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes in serum levels of the found in inflammatory zone 2(FIZZ2)and interleukin-33(IL-33)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and their correlation with prognosis.Methods A total of 102 AECOPD patients admitted to Hefei Cancer Hospital of Chinese Academy of Sciences from January 2020 to January 2023 were selected as AECOPD group,and were divided into survival group(n=30)and death group(n=72)according to the prognosis.Meanwhile,60 stable COPD patients diagnosed and treated were selected as the stable period group,and 60 healthy individuals who underwent physical examinations at the same time were selected as the control group.Enzyme linked immunosorbent assay(ELISA)was used to detect serum levels of FIZZ2 and IL-33.Pearson correlation analysis was used to investigate the correlation between serum FIZZ2 and IL-33 with lung function indicators.Multivariate Logistic regression analysis was used to identify the factors affecting the prognosis of AECOPD patients.The predictive value of serum FIZZ2 and IL-33 in predicting the prognosis of AECOPD patients was analyzed by receiver operating characteristic(ROC)curve.Results In AECOPD group,serum FIZZ2(212.19±48.47 ng/L)and IL-33(66.19±13.41 μg/L)were higher than those in the stable phase group(101.11±31.03ng/L,40.69±9.94μg/L)and the control group(42.33±7.65ng/L,26.17±8.10μg/L),and the differences were significant(t=15.925,26.915;12.799,20.961,all P＜0.05).The serum levels of FIZZ2 and IL-33 were negatively correlated with the forced expiratory volume in one second/predicted value ratio(FEV1％pred),forced expiratory volume in one second/forced vital capacity(FEV1/FVC),and arterial partial pressure of oxygen(r=-0.676,-0.707,-0.715;-0.662,-0.711,0.630,all P＜0.05),but were positively correlated with arterial partial pressure of carbon dioxide(r-0.712,0.689,all P＜0.05).The serum FIZZ2(254.30±53.22 ng/L)and IL-33(75.18±15.62 μg/L)in the death group were higher than those in the survival group(194.64±47.16 ng/L,62.50±12.37 μg/L),and the differences were significant(t=5.604,4.354,all P＜0.05).Serum FIZZ2(OR=1.445,95％CI:1.094～1.909)and IL-33(OR=1.701,95％CI:1.111～2.602)were independent risk factors for the prognosis of AECOPD patients.The area under the curve(95％confidence interval)of the combination of serum FIZZ2 and IL-33 in the prognosis evaluation of AECOPD patients was 0.886(0.842～0.927),which was higher than 0.834(0.798～0.890)and 0.806(0.779～0.846)of single index detection,and the differences were significant(Z=4.255,4.697,all P＜0.05).Conclusion The serum levels of FIZZ2 and IL-33 are elevated in AECOPD patients,which are related to lung function.The combination of the two may have high predictive value for the survival prognosis of AECOPD patients.
