Correlation of Serum Asprosin,MIP-1 β Levels with Bone Mineral Density and Bone Metabolism Indexes in Patients with Type 2 Diabetes Mellitus Combined with Osteoporosis
10.3969/j.issn.1671-7414.2024.05.025
- VernacularTitle:2型糖尿病并发骨质疏松患者血清Asprosin,MIP-1β水平与骨密度及骨代谢指标的相关性
- Author:
Yanqiu ZHANG
1
;
Xiaojun WANG
;
Ying ZHANG
;
Dan LIU
Author Information
1. 承德市中心医院内分泌科,河北承德 067000
- Keywords:
Asprosin;
macrophage inflammatory protein-1 β;
type 2 diabetes mellitus;
osteoporosis
- From:
Journal of Modern Laboratory Medicine
2024;39(5):135-139,145
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum Asprosin,macrophage inflammatory protein-1 β(MIP-1 β)levels and bone mineral density and bone metabolism indexes in patients with type 2 diabetes mellitus(T2DM)combined with osteoporosis.Methods A tatal of 172 patients with T2DM attending Chengde City Central Hospital from April 2022 to April 2023 were selected for the study,and they were divided into T2DM group(n=103)and T2DM combined with osteoporosis group(n=69)according to the results of bone mineral density.Serum Asprosin and MIP-1 β levels were measured by ELISA.Pearson method was used to analyze the correlation between serum Asprosin,MIP-1 β expression levels and bone mineral density.Logistic regression was used to analyze the factors affecting T2DM combined with osteoporosis,and the receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum Asprosin and MIP-1 β level on T2DM combined with osteoporosis.Results Compared with the T2DM group,patients in the T2DM combined with osteoporosis group had higher levels of serum β-CTX(0.48±0.08ng/ml vs 0.42±0.04ng/ml),Asprosin(2.26±0.56ng/ml vs 1.65±0.36ng/ml)and MIP-1 β(26.01±6.43pg/ml vs 19.46±4.27pg/ml),while BMD(0.67±0.13g/cm2 vs 0.84±0.17g/cm2),BGP(8.33±1.23ng/ml vs 9.54±1.42ng/ml)and T-P1NP(30.38±3.27ng/ml vs 32.49±3.29ng/ml)levels were decreased,with statistically significant differences(t=6.501,8.699,8.032,7.039,5.773,4.133,all P＜0.05).Pearson method analysis showed that serum Asprosin and MIP-1 β levels were negatively correlated with bone mineral density of patients in the T2DM combined with osteoporosis group(r=-0.484,-0.498,all P＜0.05).Logistic regression analysis showed that serum Asprosin and MIP-1 βlevels were independent risk factors influencing the occurrence of T2DM combined with osteoporosis(all P＜0.05).ROC curve analysis showed that the AUCs of serum Asprosin and MIP-1 β levels predicted T2DM combined osteoporosis were 0.768 and 0.704,respectively,and the AUC of both combined prediction was 0.859,which was better than the two alone(Z=1.812,2.895,all P＜0.05).Conclusion Serum Asprosin and MIP-1 β levels are elevated in patients with T2DM combined with osteoporosis,and both are closely related to bone mineral density.Serum Asprosin and MIP-1 β are independent risk factors for the development of T2DM combined with osteoporosis,and the joint detection of the two tests may have high predictive value for the development of the disease.
