Correlation Analysis between Serum sST2 and NLRP3 Levels in Patients with Acute Coronary Syndrome and No Reflow or Slow Re-Flow after Interventional Surgery
10.3969/j.issn.1671-7414.2024.04.022
- VernacularTitle:急性冠脉综合征患者血清sST2及NLRP3水平与介入术后无复流-慢血流的相关性分析
- Author:
Rui LEI
1
;
Shi YIN
;
Zhi LI
Author Information
1. 佳木斯市中心医院心内三科,黑龙江佳木斯 154002
- Keywords:
acute coronary syndrome;
percutaneous coronary intervention;
no reflow or slow re-flow;
soluble growth stimulation expression gene 2 protein;
nucleotide oligomerization domain like receptor heat protein domain associated protein 3
- From:
Journal of Modern Laboratory Medicine
2024;39(4):121-125,154
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum soluble growth stimulation expression gene 2 protein(sST2)and nucleotide oligomerization domain like receptor heat protein domain associated protein 3(NLRP3)levels in patients with acute coronary syndrome(ACS)and postoperative no reflow or slow re-flow after percutaneous coronary intervention(PCI).Methods A total of 97 patients with acute coronary syndrome admitted to Jiamusi Central Hospital from January 2020 to December 2022 were selected.All patients received PCI treatment and were divided into no reflow or slow re-flow group(n=20)and control group(n=77)based on the occurrence of postoperative no reflow or slow re-flow.The serum levels of sST2 and NLRP3 were detected before surgery,and the factors affecting no reflow or slow re-flow in patients with acute coronary syndrome after PCI were analyzed.The value of sST2 and NLRP3 in predicting no reflow or slow re-flow in patients with acute coronary syndrome after PCI was also analyzed.Results The serum levels of sST2(14.32±2.65 ng/ml vs 11.02±2.13 ng/ml)and NLRP3(68.23±10.17 pg/ml vs 42.05±8.23 pg/ml)in the no reflow or slow re-flow group were higher than those in the control group,and the differences were statistically significant(t=5.860,12.055,all P＜0.05).Multivariate logistic regression analysis showed that high thrombotic burden(OR=7.791,95％CI:2.834～21.421),high levels of sST2(OR=2.071,95％CI=1.146～3.743),and high levels of NLRP3(OR=2.008,95％CI:1.228～3.284)were risk factors for no reflow or slow re-flow in patients with acute coronary syndrome after PCI(all P＜0.05).The critical values of sST2 and NLRP3 for diagnosing no reflow or slow re-flow in patients with acute coronary syndrome after PCI were 12.91 ng/ml and 55.39 pg/ml,with areas under the curve of 0.737 and 0.686,respectively.The area under the curve of combined with sST2 and NLRP3 for diagnosing no reflow or slow re-flow in patients with acute coronary syndrome after PCI was 0.907,which was higher than that of individual diagnosis(Z=2.662,2.856,all P＜0.05).Conclusion The elevated levels of serum sST2 and NLRP3 in patients with acute coronary syndrome were related to the occurrence of no reflow or slow re-flow after PCI.The combination of sST2 and NLRP3 could improve the diagnostic efficacy of postoperative no reflow or slow blood flow.
