Research Progress on the Mechanism of Action and Targeting of Traditional Chinese Medicine Polysaccharides
- VernacularTitle:中药多糖作用机制与靶向性的研究进展
- Author:
Yue HOU
1
;
Can JIN
;
Chang WEN
;
Kan DING
Author Information
- Keywords: Traditional Chinese medicine; Polysaccharide; Targeting; Mechanism of action; Bibliometric analysis
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2024;26(5):1142-1161
- CountryChina
- Language:Chinese
- Abstract: Polysaccharides are the main active ingredients in traditional Chinese medicine and ideal raw materials for new drug development with diverse structures,rich activity and low toxicity.Research has shown that traditional Chinese medicine polysaccharides(TCMP)exhibit outstanding associated activities in anti-tumor,immunomodulatory,anti-fibrotic,and Alzheimer's disease prevention,with clear mechanisms and targeting properties.In this review,we discuss research progress of the mechanisms and discovery of target molecules of TCMP in various areas,including anticancer,immunomodulation,gut microbiota regulation,anti-fibrosis,and Alzheimer's disease prevention.By analyzing relevant literature,it has been observed that TCMP exhibits various complex mechanisms of action,highlighting significant targeting properties in immunomodulation,anticancer effects and disrupts angiogenesis activities.At the same time,this review summarizes and analyzes the current shortcomings and challenges in the research on TCMP and proposes future directions,aiming to provide new ideas and strategies for understanding the basis of active substances in traditional Chinese medicine and the development of original new drugs based on polysaccharides.
