Treadmill exercise promotes myelin regeneration in rats with controlled cortical impact

VernacularTitle:跑台训练促进可控性皮质损伤大鼠髓鞘再生
Author: Dandan GAO ¹ ; Kunyuan ZHU ; Shijun BI ; Yang GAO
Author Information

1. 中国人民解放军北部战区总医院神经外科,沈阳 110016
Keywords: controlled cortical impact(CCI); treadmill exercise; myelin regeneration; irisin; oligodendrocyte rat
From: Chinese Journal of Neuroanatomy 2024;40(2):241-244,256
CountryChina
Language:Chinese
Abstract: Objective:To study the effect of treadmill training on myelin regeneration in rats with controlled cortical impact(CCI).Methods:The rat CCI model of was prepared by impinging method,and the rat model was trained by running on the treadmill for 8 weeks.The neural function deficit was detected by the modified neurological function se-verity scoring method,the motor function of the rats was detected by the balance beam test,and the expression of BDNF was detected by enzyme-linked immunosorbent assay(ELISA)and RT-qPCR.The expressions of myelin basic protein(MBP),myelin oligodendrocyte glycating protein(MOG)and myelin protein lipoprotein(PLP)in corpus callosum were detected by Western Blot.Results:Treadmill training improved the neural function score and motor function of CCI injured rats,increased the expression of BDNF in cortex,and upregulated the expression of MBP,MOG,and PLP.Conclusion:Treadmill training promotes myelin repair by upregating BDNF,thereby improving the neural function defi-cit caused by CCI injury.