A retrospective cohort study of patients with type 2 diabetes mellitus to explore the impact of fasting glucose on the incidence of malignant tumors in Minhang District,Shanghai
10.3969/j.issn.1672-8467.2024.03.007
- VernacularTitle:上海市闵行区2型糖尿病患者空腹血糖对恶性肿瘤发病率影响的回顾性队列研究
- Author:
Pu LIU
1
;
Jun LI
;
Hui-Lin XU
Author Information
1. 上海市闵行区颛桥社区卫生服务中心 上海 201108
- Keywords:
type 2 diabetes mellitus(T2DM);
malignant tumors;
fasting glucose
- From:
Fudan University Journal of Medical Sciences
2024;51(3):338-343
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the incidence of malignant tumors in type 2 diabetes mellitus(T2DM)patients and the effect of fasting blood glucose(FBG)on the incidence.Methods A record linkage was carried out between Cancer Registry System in Shanghai and the electronic health record(EHR)of residents in Minhang District during 2004-2020,then a retrospective cohort study was conducted for analysis.Fasting blood glucose classification was conducted with Q1 group(＜7.0 mmol/L),Q2 group(7.0-7.9 mmol/L),Q3 group(8.0-9.7 mmol/L),and Q4 group(≥9.8 mmol/L).To quantify the hazard and effect on the risk of cancer incidence in diabetic patients,the Cox regression model and restricted cubic splines(RCS)were used.Results The study included 70 361 subjects in total,with a male to female ratio of 49.03%to 50.97%,an average age of(63.15±10.56)years,and an average follow-up time of(9.25±4.38)years.Malignant tumor incidence rate was 868.14/100 000 person years,while male 939.87/100 000 person years,female 801.85/100 000 person years,respectively.And the incidence of malignant tumor decreased with the duration of the disease(P＜0.05).With an OR of 1.44(95%CI:1.33-1.56),Q3 group had the highest influence on the incidence of malignant tumors in multivariate analysis when compared to Q1 group.After adjusted the impact of age,the RCS graphs revealed a nonlinear trend in which the incidence of malignant tumors increased initially,then slowed down or decreased with an increase in mean glucose fasting,and the difference was statistically significant(Pnonlinear＜0.05).Conclusion With high incidence of malignant tumors in T2DM patients,the impact of glucose fasting on the incidence of malignant tumors does not depend entirely on the concentration.
