Impairment of non-specific immunity in patients under persistent vegetative state resulting from trauma
- Author:
Jian CHEN
1
;
Wenji ZHENG
;
Guanghui WU
Author Information
1. 254th Hospital of PLA
- Keywords:
Immunity;
Wounds and injuries;
HLADR antigens
- From:
Chinese Journal of Traumatology
2001;4(4):214-217
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the immune response in patients under persistent vegetative state (PVS) resulting from trauma.Methods: Peripheral blood monocytes were obtained from 12 PVS patients (Group PVS )and individuals in normal control group by density gradient centrifugation;the enzyme linked immunosorbent assay kit was then used to measure monocyte HLA-DR antigen expression on the surface of peripheral blood monocytes before and after monocyte activation with either IFN-γ or LPS.Results: Compared with normal control group, the peripheral blood monocyte HLA-DR antigen expression in the Group PVC fell significantly in PVS patients (P ＜0.001); the level of HLA-DR antigen expression on the monocyte surface rose notably after stimulation with either IFN-γ or LPS (P ＜0.01). As for PVS patients, it was still difficult to restore to normal (P ＜ 0.05).Conclusions: The level of HLA-DR antigen expression on the surface of peripheral blood monocytes in PVS patients decreases obviously. Therefore, the function of non-specific immunity in PVS patients is suppressed.
