Protective effect of ischemic preconditioning on liver
- Author:
Yanzhong ZHANG
1
;
Baigen ZHANG
;
Renlong PAN
Author Information
1. 上海第二医科大学附属同济医院
- Keywords:
Ischemic preconditioning;
Liver;
Wounds and injuries;
Ischemia-reperfusion
- From:
Chinese Journal of Traumatology
2001;4(2):123-125
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the protective effect of ischemicpreconditioning (IPC) on the hepatic ischemia-reperfusion injury.Methods: The model of rat liver subjected to ischemia/reperfusion (I/R) injury was made. All 24 mice were divided randomly into 3 groups and anesthetized by 2% sodium pentobarbital (30-40 mg/kg). The enzyme activity of AST, ALT, LDH, SOD and the content of LPO were assayed respectively. Specimens were observed under transmission electron microscope.Results: IPC prevented the increase of ALT, AST and LDH in the blood and that of LPO in the tissues (P<0.05), and maintained high level of SOD in the tissues (P<0.05).Conclusions: IPC has protective effect on the liver function.
