Association of GMF-β expression with Ki-67 and its significance in the prognostic evaluation of astrocytoma
10.3760/cma.j.cn112151-20210627-00459
- VernacularTitle:星形胶质细胞瘤中神经胶质细胞成熟因子β和Ki-67表达的相关性及其在预后评估中的意义
- Author:
Xiaoyan KUANG
1
;
Senlin XU
;
Wei CUI
;
Xuefeng JIANG
Author Information
1. 陆军军医大学（原第三军医大学）西南医院病理学研究所 西南癌症中心，重庆400038
- Keywords:
Astrocytoma;
Glia maturation factor;
Ki-67 antigen;
Prognosis
- From:
Chinese Journal of Pathology
2021;50(11):1252-1256
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To clarify the correlation of the expression of glia maturation factor-β (GMF-β) with Ki-67 in astrocytoma, and to investigate the prognostic implications of combined detection of GMF-β and Ki-67.Methods:One hundred and forty human astrocytoma samples (WHO Ⅱ-Ⅳ grade) were collected at Southwest Hospital, Army Medical University (the Third Military Medical University), China from 2006 to 2009. Clinicopathological information and 3-year follow-up data were collected. Expression of GMF-β and Ki-67 was detected by single and double immunohistochemical staining, then the association of GMF-β expression with Ki-67 and its significance in prognostic evaluation of astrocytoma were statistically analyzed.Results:GMF-β expression in astrocytoma cells was correlated to both tumor grade and Ki-67 (both P<0.05); Kaplan-Meier survival analysis showed that GMF-β and Ki-67 expression were negatively correlated to the 3 year-survival rates, respectively (both P<0.01). Further analysis demonstrated that the two factors were co-influenced on survival, showing a trend of "GMF-β low Ki-67 low>GMF-β high Ki-67 low>GMF-β low Ki-67 high>GMF-β high Ki-67 high" in 3-year survival rate with significant intergroup differences ( P<0.05, P<0.01). Conclusions:GMF-β expression is positively associated with Ki-67 in astrocytoma. Combined detection of GMF-β and Ki-67 can predict prognosis of patients with glioma.
